Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats.
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منابع مشابه
Photochemical stroke model: flunarizine prevents sensorimotor deficits after neocortical infarcts in rats.
We produced unilateral photochemical infarcts in the hindlimb sensorimotor neocortex of 186 rats by intravenous injection of the fluorescein derivative rose bengal and focal illumination of the intact skull surface. Infarcted rats showed specific, long-lasting deficits in tactile and proprioceptive placing reactions of the contralateral limbs, mostly the hindlimb. Placing deficits were most pro...
متن کاملReplacing neocortical neurons after stroke.
Fifteen years ago, a research report claiming that brain injury stimulates production of new neurons in postnatal mammalian forebrain would have been met with widespread skepticism. Since then, considerable experimental evidence has emerged indicating that neural stem cells and neurogenesis persist in specific regions of the neonatal and adult mammalian forebrain (reviewed in Ming and Song). Ma...
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OBJECTIVE To evaluate the safety and tolerability of dalfampridine extended release (D-ER) in participants with chronic post-ischemic stroke deficits, and to assess for potential drug activity on sensorimotor function. METHODS Using a double-blind, placebo-controlled, cross-over design, participants were randomized to placebo/D-ER or D-ER/placebo sequences and given D-ER 10 mg or placebo twic...
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BACKGROUND AND PURPOSE Stroke survivors often have permanent deficits that are only partially addressed by physical therapy. This study evaluated the effects of dalfampridine, a potassium channel blocker, on persistent sensorimotor deficits in rats with treatment initiated 4 or 8 weeks after stroke. METHODS Rats underwent permanent middle cerebral artery occlusion. Sensorimotor function was m...
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ژورنال
عنوان ژورنال: Stroke
سال: 1989
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.20.10.1383